frequency of adenocarcinoma in transrectal ultrasound-guided prostate needle biopsies in men with clinical suspicion of prostate cancer and raised serum prostate specific antigen
نویسندگان
چکیده
background : a transrectal ultrasound-guided prostate biopsy is currently the gold standard procedure to detect prostatic adenocarcinoma. there is little information on the clinical utility of this technique for the detection of prostate adenocarcinoma in men with suspected prostate cancer in pakistan. this study seeks to determine the frequency of prostatic adenocarcinoma by using a transrectal ultrasound-guided octant prostate needle biopsy protocol in men with clinical suspicion of cancer. methods : all adult men, aged ≥40 years that consecutively presented with signs and symptoms of prostatism, an abnormal digital rectal examination and/or elevated serum total prostate specific antigen levels at sindh institute of urology and transplan- tation, karachi, pakistan from march 2011 to february 2012, and who underwent transrectal ultrasound-guided biopsies were included. in most patients, eight cores were taken per case. each core was separately labeled and processed for histopathological evaluation. results : a total of 203 men underwent transrectal ultrasound-guided prostate biopsies during the study period. the mean age of all patients was 65.7±9.3 years. the median serum total prostate specific antigen level was 21.6 ng/ml. the overall frequency of detection of prostate adenocarcinoma in this cohort was 48.8% (99/203). the mean number of positive cores per case was 6.02±2.25; the minimum was one and the maximum, eight. conclusion : this study showed a similar detection rate for prostate cancer to that reported in studies from asian and western countries. the detection rate was markedly higher compared to a few local studies, which showed a very low incidence because of the unavailability of transrectal ultrasound-guided needle biopsies and lack of prostate specific antigen screening programs.
منابع مشابه
Frequency of Adenocarcinoma in Transrectal Ultrasound-guided Prostate Needle Biopsies in Men with Clinical Suspicion of Prostate Cancer and Raised Serum Prostate Specific Antigen
Email: [email protected] Abstract Background: A transrectal ultrasound-guided prostate biopsy is currently the gold standard procedure to detect prostatic adenocarcinoma. There is little information on the clinical utility of this technique for the detection of prostate adenocarcinoma in men with suspected prostate cancer in Pakistan. This study seeks to determine the frequency of prostat...
متن کاملhistopathological lesions in transrectal ultrasound guided biopsies of prostate in patients with raised serum prostate specific antigen: a preliminary report
متن کامل
Age Specific Reference Levels of Serum Prostate-Specific Antigen, Prostate Volume and Prostate Specific Antigen Density in Healthy Iranian Men
Background: It is relevant to highlight that there is not a precise and perfect report on either 95 percentile value (upper limit of normal range) or on appropriate reference intervals for serum PSA in Iranian population. Objective: To determine age-specific reference ranges for serum prostate-specific antigen (PSA) concentration and PSA density (PSAD) and prostate volumes in a population of he...
متن کاملProstate specific antigen staining intensity in prostatic adenocarcinoma correlates with serum prostate specific antigen , Bandar Abbas, Iran
Introduction: Prostatic adenocarcinoma is one the most common malignances and the second cause of death in males due to cancer. Prostate Specific Antigen (PZSA) serum level is the first marker to screen such patients. We aimed in this study, to assess the intensity of prostatic adenocarcinoma tissue staining with PSA staining method. Methods: In this corss-sectional study, prostatic adenocarcin...
متن کاملage specific reference levels of serum prostate-specific antigen, prostate volume and prostate specific antigen density in healthy iranian men
background: it is relevant to highlight that there is not a precise and perfect report on either 95 percentile value (upper limit of normal range) or on appropriate reference intervals for serum psa in iranian population. objective: to determine age-specific reference ranges for serum prostate-specific antigen (psa) concentration and psa density (psad) and prostate volumes in a population of he...
متن کاملAssociation between rs2735839 and Serum Prostate-specific Antigen Level Regarding Risk of Prostate Cancer in Iranian Population
Background and Objective: Prostate cancer is among the five common cancers in males. It is second cancer in terms of the age-standardized rate (ASR) (ASR=16.6) in Iran. The rs2735839 G/A, an intergenic polymorphism is located on chromosome 19q13.33 at 600 base pairs of the KLK3 gene untranslatable region. This gene which codes prostate-specific antigen (PSA) is used in the screening and diagnos...
متن کاملمنابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
middle east journal of cancerجلد ۴، شماره ۲، صفحات ۷۳-۰
میزبانی شده توسط پلتفرم ابری doprax.com
copyright © 2015-2023